The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer

2011121 citationsJournal Articlehybrid Open Access

Authors

Sune B. Villadsen

Jesper B. Bramsen · Aarhus University

Marie S. Ostenfeld · Aarhus University Hospital

Erik D. Wiklund · Aarhus University

Niels Fristrup · Aarhus University Hospital

Shan Gao · Aarhus University

Thomas B. Hansen · Aarhus University

Abstract

This report provides the first evidence for direct miRNA regulation of PAI-1 in bladder cancer. We also demonstrate mRNA co-targeting by a cluster of non-family miRNAs, and suggest miR-145 and PAI-1 as clinically relevant biomarkers in bladder cancer.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Extracellular vesicles in disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 106, Issue 2, pp. 366-374

DOI: 10.1038/bjc.2011.520

Field-Weighted Citation Impact: 4.04