Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice

201085 citationsJournal Articlegold Open Access

Authors

Siva K. Panguluri · University of Louisville

Shephali Bhatnagar · University of Louisville

Akhilesh Kumar · University of Louisville

John J. McCarthy · University of Kentucky

Apurva K. Srivastava · University of Louisville

Nigel G. F. Cooper ·

Abstract

Our results suggest that TWEAK affects the expression of several genes and microRNAs involved in inflammatory response, fibrosis, extracellular matrix remodeling, and proteolytic degradation which might be responsible for TWEAK-induced skeletal muscle loss.

Topics & Keywords

Muscle Physiology and Disorders NF-κB Signaling Pathways RNA regulation and disease

Publication Details

Published in: PLoS ONE

Volume 5, Issue 1, pp. e8760-e8760

DOI: 10.1371/journal.pone.0008760

Field-Weighted Citation Impact: 4.07

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Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice

Authors

Abstract

Topics & Keywords

Publication Details