Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

201210,393 citationsJournal Articlegreen Open Access

Authors

Maj-Linda B. Selenica · University of South Florida

Milene L. Brownlow · University of South Florida

Jeffy P. Jimenez · University of South Florida

Daniel C. Lee · University of South Florida

Gabriela Peña · University of South Florida

Chad A. Dickey · University of South Florida

Marcia N. Gordon

Abstract

Soluble Aβ(1-42) oligomers have long-lasting effects on tau phosphorylation in the rTg4510 model, possibly due to elevations in GSK3. These data suggest that even brief elevations in Aβ production, may have enduring impact on the risk for tauopathy.

Topics & Keywords

Alzheimer's disease research and treatments Prion Diseases and Protein Misfolding Endoplasmic Reticulum Stress and Disease

Publication Details

Published in: Neurodegenerative Diseases

Volume 11, Issue 4, pp. 165-181

DOI: 10.1159/000337230

Field-Weighted Citation Impact: 262.55

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Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Authors

Abstract

Topics & Keywords

Publication Details