MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma #

2008580 citationsJournal Articlebronze Open Access

Authors

Wei-Chih Tsai · National Yang Ming Chiao Tung University

Paul Wei‐Che Hsu · National Yang Ming Chiao Tung University

Tsung‐Ching Lai · Genomics Research Center, Academia Sinica

Gar‐Yang Chau · Taipei Veterans General Hospital

Ching‐Wen Lin · National Yang Ming Chiao Tung University

Chun‐Ming Chen · National Yang Ming Chiao Tung University

Chien-Der Lin

Abstract

Our study suggests that miR-122, a tumor suppressor microRNA affecting hepatocellular carcinoma intrahepatic metastasis by angiogenesis suppression, exerts some of its action via regulation of ADAM17. Restoration of miR-122 has a far-reaching effect on the cell. Using the concomitant down-regulation of its targets, including ADAM17, a rational therapeutic strategy based on miR-122 may prove to be beneficial for patients with hepatocellular carcinoma.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 49, Issue 5, pp. 1571-1582

DOI: 10.1002/hep.22806

Field-Weighted Citation Impact: 10.65