The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

201580 citationsJournal Article

Authors

Jessica M. Mc Donald · Brigham and Women's Hospital

Tiernan T. O’Malley · Brigham and Women's Hospital

Wen Liu · Brigham and Women's Hospital

Alexandra J. Mably · Brigham and Women's Hospital

Gunnar Brinkmalm · Sahlgrenska University Hospital

Erik Portelius · Sahlgrenska University Hospital

William M. Wittbold

Abstract

Further analysis of brain-derived ∼7 kDa Aβ species, the mechanism by which they assemble and the structures they form should reveal therapeutic and diagnostic opportunities.

Topics & Keywords

Alzheimer's disease research and treatments Computational Drug Discovery Methods Cholinesterase and Neurodegenerative Diseases

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Alzheimer s & Dementia

Volume 11, Issue 11, pp. 1286-1305

DOI: 10.1016/j.jalz.2015.01.005

Field-Weighted Citation Impact: 4.71