Ibuprofen delivered by poly(lactic-co-glycolic acid) (PLGA) nanoparticles to human gastric cancer cells exerts antiproliferative activity at very low concentrations

201231 citationsJournal Articlegold Open Access

Authors

Patrizia Bonelli

Franca Maria Tuccillo · Organogenesis (United States)

Antonella Federico · Creatv MicroTech (United States)

Maria Napolitano · Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Antonella Borrelli · Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Daniela Melisi · Federico II University Hospital

Maria Grazia Rimoli · Federico II University Hospital

Abstract

Ibuprofen exerted an antiproliferative effect on MKN-45 cells at low concentrations. This effect was achieved using PLGA NPs as carriers of low doses of ibuprofen.

Topics & Keywords

Inflammatory mediators and NSAID effects Peptidase Inhibition and Analysis Chemokine receptors and signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Journal of Nanomedicine

Volume 7, pp. 5683-5683

DOI: 10.2147/ijn.s34723

Field-Weighted Citation Impact: 0.81