Magnetic Targeted Delivery of Dexamethasone Acetate Across the Round Window Membrane in Guinea Pigs

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Authors

Xiaoping Du · Hough Ear Institute

Kejian Chen · Hough Ear Institute

Satish I. Kuriyavar · Hough Ear Institute

Richard D. Kopke · Hough Ear Institute

Brian P. Grady · University of Oklahoma

David H. Bourne

Wei Li · Hough Ear Institute

Abstract

Superparamagnetic PLGA-magnetite-Dex-Ac nanoparticles under an external magnetic field (0.26 mT) for 1 hour significantly increased Dex-Ac delivery to the inner ear. The RWM was not completely permeated and also became loaded with nanocomposites, indicating that delivery to the cochlea would continue for weeks by PLGA degradation and passive diffusion.

Topics & Keywords

Vestibular and auditory disorders Hearing, Cochlea, Tinnitus, Genetics Ear Surgery and Otitis Media

Publication Details

Published in: Otology & Neurotology

Volume 34, Issue 1, pp. 41-47

DOI: 10.1097/mao.0b013e318277a40e

Field-Weighted Citation Impact: 2.11

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Magnetic Targeted Delivery of Dexamethasone Acetate Across the Round Window Membrane in Guinea Pigs

Authors

Abstract

Topics & Keywords

Publication Details