Insulin-Resistant Prediabetic Subjects Have More Atherogenic Risk Factors Than Insulin-Sensitive Prediabetic Subjects

2000456 citationsJournal Article

Authors

Steven M. Haffner · The University of Texas Health Science Center at San Antonio

Leena Mykkänen · The University of Texas Health Science Center at San Antonio

Andreas Festa · The University of Texas Health Science Center at San Antonio

J. P. Burke · The University of Texas Health Science Center at San Antonio

Michael P. Stern · The University of Texas Health Science Center at San Antonio

Abstract

Our data suggest that atherogenic changes in the prediabetic state are mainly seen in insulin-resistant subjects and that strategies to prevent type 2 diabetes might focus on insulin-sensitizing interventions rather than interventions that increase insulin secretion because of potential effects on cardiovascular risk.

Topics & Keywords

Diabetes, Cardiovascular Risks, and Lipoproteins Cardiovascular Function and Risk Factors Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 101, Issue 9, pp. 975-980

DOI: 10.1161/01.cir.101.9.975

Field-Weighted Citation Impact: 22.84