A Novel Method for Detection of Phosphorylation in Single Cells by Surface Enhanced Raman Scattering (SERS) using Composite Organic-Inorganic Nanoparticles (COINs)

200945 citationsJournal Articlegold Open Access

Authors

Catherine M. Shachaf · Stanford University

Sailaja Elchuri · Stanford University

Ai Leen Koh · Stanford University

Jing Zhu · Intel (United States)

Lienchi Nguyen · Intel (United States)

Dennis J. Mitchell · Stanford University

Jingwu Zhang ·

Abstract

Thus, we have demonstrated the practicality of applying COIN nanoparticles for measuring intracellular phosphorylation, offering new possibilities to expand on the current fluorescent technology used for immunoassays in single cells.

Topics & Keywords

Advanced biosensing and bioanalysis techniques Gold and Silver Nanoparticles Synthesis and Applications Biosensors and Analytical Detection

Publication Details

Published in: PLoS ONE

Volume 4, Issue 4, pp. e5206-e5206

DOI: 10.1371/journal.pone.0005206

Field-Weighted Citation Impact: 2.96

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A Novel Method for Detection of Phosphorylation in Single Cells by Surface Enhanced Raman Scattering (SERS) using Composite Organic-Inorganic Nanoparticles (COINs)

Authors

Abstract

Topics & Keywords

Publication Details