Decreased FOXP3 protein expression in patients with asthma

2009152 citationsJournal Article

Authors

Sharen Provoost · Ghent University Hospital

Tania Maes · Ghent University Hospital

Y. M. Van Durme · Ghent University Hospital

Philippe Gevaert · Ghent University Hospital

Claus Bachert · Ghent University Hospital

Carsten B. Schmidt‐Weber · Imperial College London

Guy Brusselle

Abstract

Asthmatic patients have decreased FOXP3 protein expression within their CD4(+)CD25(high) T(reg). Our findings also suggest that treatment with inhaled glucocorticosteroids in asthmatics might increase this FOXP3 protein expression within the CD4(+)CD25(high) T-cell population.

Topics & Keywords

Immune Cell Function and Interaction IL-33, ST2, and ILC Pathways Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Allergy

Volume 64, Issue 10, pp. 1539-1546

DOI: 10.1111/j.1398-9995.2009.02056.x

Field-Weighted Citation Impact: 5.34