Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

2012695 citationsJournal Article

Authors

Chunyi Sun

Chao Qin · Northeast Normal University

Xinlong Wang · Northeast Normal University

Guang‐Sheng Yang · Northeast Normal University

Kui‐Zhan Shao · Northeast Normal University

Ya‐Qian Lan · Northeast Normal University

Zhong‐Min Su · Northeast Normal University

Abstract

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

Topics & Keywords

Metal-Organic Frameworks: Synthesis and Applications Nanoplatforms for cancer theranostics Covalent Organic Framework Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Dalton Transactions

Volume 41, Issue 23, pp. 6906-6906

DOI: 10.1039/c2dt30357d

Field-Weighted Citation Impact: 9.61