Adropin Is a Novel Regulator of Endothelial Function

2010301 citationsJournal Articlebronze Open Access

Authors

Fina Lovren · University of Toronto

Yi Pan · University of Toronto

Adrian Quan · McMaster University

Krishna K. Singh · King Khalid University Hospital

Praphulla Chandra Shukla · William Osler Health System

Milan Gupta · King Khalid University Hospital

Mohammed Al‐Omran ·

Abstract

We report a potential endothelial protective role of adropin that is likely mediated via upregulation of endothelial NO synthase expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and VEGFR2-extracellular signal regulated kinase 1/2 pathways. Adropin represents a novel target to limit diseases characterized by endothelial dysfunction in addition to its favorable metabolic profile.

Topics & Keywords

Adipose Tissue and Metabolism Mitochondrial Function and Pathology Cardiac Ischemia and Reperfusion

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Circulation

Volume 122, Issue 11_suppl_1, pp. S185-92

DOI: 10.1161/circulationaha.109.931782

Field-Weighted Citation Impact: 2.91