Upregulation of the CD40/CD40 Ligand Dyad and Platelet-Monocyte Aggregation in Cigarette Smokers

2004118 citationsJournal Article

Authors

S. Harding · Edinburgh Royal Infirmary

Jaydeep Sarma · Edinburgh Royal Infirmary

Debra H. Josephs · Edinburgh Royal Infirmary

Nicholas L. Cruden · Edinburgh Royal Infirmary

Jehangir Din · Edinburgh Royal Infirmary

Patrick J. Twomey · Edinburgh Royal Infirmary

Keith A.A. Fox

Abstract

Cigarette smokers have upregulation of the CD40/CD40L dyad and platelet-monocyte aggregation that may account for the atherothrombotic consequences of this major cardiovascular risk factor.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Atherosclerosis and Cardiovascular Diseases Chemokine receptors and signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 109, Issue 16, pp. 1926-1929

DOI: 10.1161/01.cir.0000127128.52679.e4

Field-Weighted Citation Impact: 6.10