Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression

200968 citationsJournal Articlegold Open Access

Authors

Shunsuke Hasegawa · Tokyo University of Agriculture

Takahiro Furuichi · Tokyo University of Agriculture

Taro Yoshida · Tokyo University of Agriculture

Kengo Endoh · Tokyo University of Agriculture

Kenichi Kato · Tokyo University of Agriculture

Megumi Sado · Tokyo University of Agriculture

Ryouta Maeda

Abstract

Up-regulation of alpha-CaMKII expression in the forebrain leads to an increase in anxiety-like behaviors and offensive aggression. From the comparisons with previous findings, we suggest that the expression levels of alpha-CaMKII are associated with the state of emotion; the expression level of alpha-CaMKII positively correlates with the anxiety state and strongly affects aggressive behavior.

Topics & Keywords

Neuroscience and Neuropharmacology Research Memory and Neural Mechanisms Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Molecular Brain

Volume 2, Issue 1, pp. 6-6

DOI: 10.1186/1756-6606-2-6

Field-Weighted Citation Impact: 1.97