Macroporous Calcium Phosphate Ceramic Performance in Human Spine Fusion

With a background of experimental studies on macroporous biphasic calcium phosphate (MBCP) in canine spine fusion, MBCP was investigated in 11- to 18-year-old patients with scoliosis treated by spinal fusion. Twelve cases were chosen for whom enough bone graft was difficult to obtain (severe neurologic scoliosis and osteogenesis imperfecta). MBCP blocks were used in combination with a specific strong fixation (Cotrel-Dubousset instrumentation). Clinical and roentgenogram assessments were performed up to 24 months. In two cases, biopsies were obtained. Histologic, ultrastructural, and microanalysis studies demonstrated the effectiveness of MBCP implants combined with a strong stabilization as bone graft substitutes for spine fusion. Clinical and biologic assessments were normal, and the histologic and ultrastructural evaluation demonstrated the bioactivity and the osteoconduction of this material. Partial resorbability of the MBCP blocks involved lamellar bone formation at the expense of the ceramic.