Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes

201519 citationsJournal Articlegold Open Access

Authors

Thomas Dschietzig · Clínica Sagrada Esperança

Katharina Krause-Relle · Charité - Universitätsmedizin Berlin

Maud Hennequin · Freie Universität Berlin

Karoline von Websky · University of Potsdam

Jan Rahnenführer · University of Potsdam

Jana Ruppert · Immundiagnostik (Germany)

Hans Jürgen Grön

Abstract

We investigated a model showing early DN without overt tubulointerstitial fibrosis and activation of the TGF-β-Smad-2/3 pathway. In this model, Rlx proved ineffective; however, the same may not apply to other models and types of diabetes.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Kidney & Blood Pressure Research

Volume 40, Issue 1, pp. 77-88

DOI: 10.1159/000368484

Field-Weighted Citation Impact: 2.98