Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

2011239 citationsJournal Articlegold Open Access

Authors

Subbiah Pugazhenthi · University of Colorado Denver

Serena Pham · Veterans Health Administration

Chun‐I Sze · National Cheng Kung University

Christopher B. Eckman · Atlantic Health System

Abstract

Our findings suggest that chronic downregulation of CREB-mediated transcription results in decrease of CREB content in the hippocampal neurons of AD brain which may contribute to exacerbation of disease progression.

Topics & Keywords

Alzheimer's disease research and treatments Neuroscience and Neuropharmacology Research Trace Elements in Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Neurodegeneration

Volume 6, Issue 1, pp. 60-60

DOI: 10.1186/1750-1326-6-60

Field-Weighted Citation Impact: 5.02