Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

2013108 citationsJournal Articlebronze Open Access

Authors

Nikolaus Jilg · Harvard University

Wenyu Lin · Harvard University

Jian Hong · Harvard University

Esperance Schaefer · Harvard University

David Wolski · Harvard University

James Meixong · Harvard University

Kaku Goto · Tokyo Medical University

Abstract

The kinetics of gene induction are fundamentally different for stimulations with either IFN-α or IL28B in hepatocytes, suggesting distinct roles of these cytokines within the immune response. Furthermore, the observed differences are substantially altered by infection with HCV.

Topics & Keywords

Hepatitis C virus research Cytokine Signaling Pathways and Interactions Viral Infections and Immunology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 59, Issue 4, pp. 1250-1261

DOI: 10.1002/hep.26653

Field-Weighted Citation Impact: 4.01