Longer Therapy, Iatrogenic Amenorrhea, and Survival in Early Breast Cancer

2010328 citationsJournal Articlebronze Open Access

Authors

Sandra M. Swain · MedStar Washington Hospital Center

Jong‐Hyeon Jeong · University of Pittsburgh

Charles E. Geyer · MedStar Washington Hospital Center

Joseph P. Costantino · University of Pittsburgh

Eduardo R. Pajon · University of Colorado Denver

Louis Fehrenbacher · Kaiser Permanente Vallejo Medical Center

James N. Atkins

Abstract

Sequential ACT improved disease-free survival as compared with doxorubicin-docetaxel or concurrent ACT, and it improved overall survival as compared with doxorubicin-docetaxel. Amenorrhea was associated with improved survival regardless of the treatment and estrogen-receptor status. (ClinicalTrials.gov number, NCT00003782.)

Topics & Keywords

Breast Cancer Treatment Studies Cancer Treatment and Pharmacology Advanced Breast Cancer Therapies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 362, Issue 22, pp. 2053-2065

DOI: 10.1056/nejmoa0909638

Field-Weighted Citation Impact: 11.45