Resuscitation With 100% Oxygen Causes Intestinal Glutathione Oxidation and Reoxygenation Injury in Asphyxiated Newborn Piglets

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Authors

Erika Haase · University of Alberta Hospital

David L. Bigam

Abstract

Resuscitation of hypoxemic newborn piglets with 100% oxygen is associated with an increase in oxygen delivery and oxidative stress, and may be associated with the development of small intestinal hypoxia-reoxygenation injury. Resuscitation of asphyxiated newborns with lower oxygen concentrations may help to decrease the risk of necrotizing enterocolitis.

Topics & Keywords

Neonatal Respiratory Health Research Respiratory Support and Mechanisms Neuroscience of respiration and sleep

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Surgery

Volume 240, Issue 2, pp. 364-373

DOI: 10.1097/01.sla.0000133348.58450.e4

Field-Weighted Citation Impact: 5.00