Association of Global DNA Methylation and Global DNA Hydroxymethylation with Metals and Other Exposures in Human Blood DNA Samples

2014116 citationsJournal Articlediamond Open Access

Authors

María Téllez-Plaza · Johns Hopkins University

Wan‐Yee Tang · Johns Hopkins University

Yan Shang · Johns Hopkins University

Jason G. Umans · MedStar Union Memorial Hospital

Kevin A. Francesconi · University of Graz

Walter Goessler · University of Graz

Marta Ledesma ·

Abstract

Our findings support that both epigenetic measures are related at the population level. The consistent trends in the associations between these two epigenetic modifications and the characteristics evaluated, especially arsenic exposure and metabolism, suggest the need for understanding which of the two measures is a better biomarker for environmental epigenetic effects in future large-scale epidemiologic studies.

Topics & Keywords

Epigenetics and DNA Methylation Health, Environment, Cognitive Aging Birth, Development, and Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Environmental Health Perspectives

Volume 122, Issue 9, pp. 946-954

DOI: 10.1289/ehp.1306674

Field-Weighted Citation Impact: 6.55