Systolic Pulmonary Artery Pressure and Heart Rate are Main Determinants of Oxygen Consumption in the Right Ventricular Myocardium of Patients with Idiopathic Pulmonary Arterial Hypertension

201143 citationsJournal Articlebronze Open Access

Authors

Yeun Ying Wong · Amsterdam UMC Location Vrije Universiteit Amsterdam

Nico Westerhof · Amsterdam UMC Location Vrije Universiteit Amsterdam

Gerrina Ruiter · Amsterdam UMC Location Vrije Universiteit Amsterdam

Mark Lubberink · Amsterdam UMC Location Vrije Universiteit Amsterdam

Pieter G. Raijmakers · Amsterdam UMC Location Vrije Universiteit Amsterdam

Paul Knaapen · Amsterdam UMC Location Vrije Universiteit Amsterdam

Abstract

Systolic PAP and HR are the major determinants of RV MVO(2) in IPAH. A further increase of HR and PAP with IPAH progression suggests a compromised RV myocardial oxygen availability.

Topics & Keywords

Pulmonary Hypertension Research and Treatments Cardiovascular Function and Risk Factors Cardiovascular Effects of Exercise

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Journal of Heart Failure

Volume 13, Issue 12, pp. 1290-1295

DOI: 10.1093/eurjhf/hfr140

Field-Weighted Citation Impact: 2.68