Effect of Alipogene Tiparvovec (AAV1-LPL<sup>S447X</sup>) on Postprandial Chylomicron Metabolism in Lipoprotein Lipase-Deficient Patients

2012163 citationsJournal Articlebronze Open Access

Authors

André C. Carpentier · Université de Sherbrooke

Frédérique Frisch

Sébastien M. Labbé

René Gagnon · Université de Sherbrooke

J. de Wal · AIMM Therapeutics (Netherlands)

S. Greentree · AIMM Therapeutics (Netherlands)

Harald Petry · AIMM Therapeutics (Netherlands)

Jaap Twisk

Abstract

Intramuscular administration of alipogene tiparvovec resulted in a significant improvement of postprandial chylomicron metabolism in LPLD patients, without inducing large postprandial NEFA spillover.

Topics & Keywords

Diabetes and associated disorders Lipid metabolism and disorders Diabetes Management and Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 97, Issue 5, pp. 1635-1644

DOI: 10.1210/jc.2011-3002

Field-Weighted Citation Impact: 11.96