MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

2002930 citationsReview

Authors

Mariska Klerk · Wageningen University & Research

Petra Verhoef

Abstract

Individuals with the MTHFR 677 TT genotype had a significantly higher risk of CHD, particularly in the setting of low folate status. These results support the hypothesis that impaired folate metabolism, resulting in high homocysteine levels, is causally related to increased risk of CHD.

Topics & Keywords

Folate and B Vitamins Research Esophageal and GI Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 288, Issue 16, pp. 2023-2023

DOI: 10.1001/jama.288.16.2023

Field-Weighted Citation Impact: 45.57