Effect of levothyroxine administration on intestinal P‐glycoprotein expression: Consequences for drug disposition*

200247 citationsJournal Article

Authors

Werner Siegmund · Universität Greifswald

Stephan Altmannsberger · Apogepha Arzneimittel (Germany)

Andrea Paneitz · Universität Greifswald

Ute Hecker · Universitätsmedizin Greifswald

M Zschiesche · Universität Greifswald

Gerd Franke · Universität Greifswald

Wieland Meng ·

Abstract

Expression of intestinal P-glycoprotein in humans appears to be influenced by thyroid hormones. The functional consequences need to be addressed in patients with hyperthyroidism.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pharmacogenetics and Drug Metabolism Gastroesophageal reflux and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 72, Issue 3, pp. 256-264

DOI: 10.1067/mcp.2002.126706

Field-Weighted Citation Impact: 1.43