CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD

2005221 citationsJournal Articlegold Open Access

Authors

Kristinn P. Magnússon · deCODE Genetics (Iceland)

Shan Duan · Sun Yat-sen University

Haraldur Sigurðsson · National University Hospital of Iceland

Hjörvar Pétursson · deCODE Genetics (Iceland)

Zhenglin Yang · Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Yu Zhao · University of Utah

Paul S. Bernstein

Abstract

Soft drusen occur prior to progression to advanced AMD and represent a histological feature shared by neovascular AMD and GA. Our results suggest that CFH is a major risk factor of soft drusen, and additional genetic factors and/or environmental factors may be required for progression to advanced AMD.

Topics & Keywords

Retinal Diseases and Treatments Retinal Imaging and Analysis Glaucoma and retinal disorders

Publication Details

Published in: PLoS Medicine

Volume 3, Issue 1, pp. e5-e5

DOI: 10.1371/journal.pmed.0030005

Field-Weighted Citation Impact: 24.12

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CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD

Authors

Abstract

Topics & Keywords

Publication Details