The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

2011112 citationsJournal Articlegold Open Access

Authors

Michel Bidet

Olivier Joubert · Centre National de la Recherche Scientifique

Benoı̂t Lacombe · Centre National de la Recherche Scientifique

Marine Ciantar · Université Côte d'Azur

Rony Nehmé · Centre National de la Recherche Scientifique

Patrick Mollat · Galapagos (France)

Lionel Brétillon · Centre des Sciences du Goût et de l'Alimentation

Abstract

Our results suggest that Patched may contribute to cholesterol efflux from cells, and to modulation of the intracellular cholesterol concentration. This activity is likely responsible for the inhibition of the enrichment of Smoothened in the plasma membrane, which is an important step in Shh pathway activation.

Topics & Keywords

Hedgehog Signaling Pathway Studies Epigenetics and DNA Methylation Genetic and rare skin diseases.

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 6, Issue 9, pp. e23834-e23834

DOI: 10.1371/journal.pone.0023834

Field-Weighted Citation Impact: 2.66