ISSLS Prize Winner: Repeated Disc Injury Causes Persistent Inflammation

2007192 citationsJournal Article

Authors

J. Ulrich · University of California, San Francisco

Ellen Liebenberg · University of California, San Francisco

Daniel Thuillier · University of California, San Francisco

Jeffrey C. Lotz · University of California, San Francisco

Abstract

Our results demonstrate that repeated injury during active healing leads to persistent inflammation and enhanced disc degeneration. These data support the premise that damage accumulation and its associated inflammation may distinguish pathologic from physiologic disc degeneration. In the future, this triple-stab model may be useful to evaluate the efficacy of anti-inflammatory low back pain treatments.

Topics & Keywords

Spine and Intervertebral Disc Pathology Musculoskeletal pain and rehabilitation Anesthesia and Pain Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Spine

Volume 32, Issue 25, pp. 2812-2819

DOI: 10.1097/brs.0b013e31815b9850

Field-Weighted Citation Impact: 6.85