TRPM7-Mediated Ca <sup>2+</sup> Signals Confer Fibrogenesis in Human Atrial Fibrillation

2010323 citationsJournal Articlegreen Open Access

Authors

Jianyang Du · ZTE (United States)

Jia Xie · ZTE (United States)

Zheng Zhang · ZTE (United States)

Hiroto Tsujikawa · ZTE (United States)

Daniel Fusco · ZTE (United States)

David I. Silverman · ZTE (United States)

Bruce T. Liang · ZTE (United States)

Abstract

Our results establish that TRPM7 is the major Ca(2+)-permeable channel in human atrial fibroblasts and likely plays an essential role in TGF-beta1-elicited fibrogenesis in human AF.

Topics & Keywords

Magnesium in Health and Disease Ion Channels and Receptors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 106, Issue 5, pp. 992-1003

DOI: 10.1161/circresaha.109.206771

Field-Weighted Citation Impact: 15.23