Dose of Prophylactic Platelet Transfusions and Prevention of Hemorrhage

2010658 citationsJournal Articlebronze Open Access

Authors

Sherrill J. Slichter · University of Washington Medical Center

Richard M. Kaufman · Brigham and Women's Hospital

Susan F. Assmann · New England Research Institutes

Jeffrey McCullough · University Medical Center

Darrell J. Triulzi · University of Pittsburgh

Ronald G. Strauss · University of Iowa

Terry Gernsheimer

Abstract

Low doses of platelets administered as a prophylactic transfusion led to a decreased number of platelets transfused per patient but an increased number of transfusions given. At doses between 1.1x10(11) and 4.4x10(11) platelets per square meter, the number of platelets in the prophylactic transfusion had no effect on the incidence of bleeding. (ClinicalTrials.gov number, NCT00128713.)

Topics & Keywords

Trauma, Hemostasis, Coagulopathy, Resuscitation Blood transfusion and management Platelet Disorders and Treatments

Publication Details

Published in: New England Journal of Medicine

Volume 362, Issue 7, pp. 600-613

DOI: 10.1056/nejmoa0904084

Field-Weighted Citation Impact: 28.68

Command Palette

Dose of Prophylactic Platelet Transfusions and Prevention of Hemorrhage

Authors

Abstract

Topics & Keywords

Publication Details