In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells

2014191 citationsJournal Articlehybrid Open Access

Authors

Pengfei Jiang · University of California, San Diego

Rajesh Mukthavaram · University of California, San Diego

Ying S. Chao · University of California, San Diego

Natsuko Nomura · University of California, San Diego

Ila Sri Bharati · University of California, San Diego

Valentina Fogal · University of California, San Diego

Sandra Pastorino

Abstract

Our study demonstrates the potent anticancer effects of statins. These safe and well-tolerated drugs need to be further investigated as cancer chemotherapeutics in comprehensive clinical studies.

Topics & Keywords

Cancer, Lipids, and Metabolism Plant biochemistry and biosynthesis Lipid metabolism and biosynthesis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 111, Issue 8, pp. 1562-1571

DOI: 10.1038/bjc.2014.431

Field-Weighted Citation Impact: 3.88