High cumulative risks of cancer in patients with <i>PTEN</i> hamartoma tumour syndrome

2013365 citationsJournal Article

Authors

Virginie Bubien · Institut Bergonié

Françoise Bonnet · Université de Bordeaux

Véronique Brouste · Institut Bergonié

Stéphanie Hoppe · Institut Bergonié

Emmanuelle Barouk-Simonet · Institut Bergonié

Albert David · Centre Hospitalier Universitaire de Nantes

Patrick Edery ·

Abstract

This study shows a considerably high cumulative risk of cancer for patients with PHTS, mainly in women without clear genotype-phenotype correlation for this cancer risk. New recommendations for the management of PHTS patients are proposed.

Topics & Keywords

PI3K/AKT/mTOR signaling in cancer Infectious Diseases and Mycology Polyamine Metabolism and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Medical Genetics

Volume 50, Issue 4, pp. 255-263

DOI: 10.1136/jmedgenet-2012-101339

Field-Weighted Citation Impact: 12.88