In Vitro Antimycobacterial Activities of Capuramycin Analogues

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Authors

Venkata M. Reddy · Sequella (United States)

Carol A. Nacy · Sequella (United States)

Abstract

Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 microg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.

Topics & Keywords

Microbial Natural Products and Biosynthesis Mycobacterium research and diagnosis Cancer therapeutics and mechanisms

Publication Details

Published in: Antimicrobial Agents and Chemotherapy

Volume 52, Issue 2, pp. 719-721

DOI: 10.1128/aac.01469-07

Field-Weighted Citation Impact: 2.54

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In Vitro Antimycobacterial Activities of Capuramycin Analogues

Authors

Abstract

Topics & Keywords

Publication Details