Immunologic Effects of Hydroxyurea in Sickle Cell Anemia

201451 citationsJournal Articlebronze Open Access

Authors

Howard M. Lederman · ENT and Allergy

Margaret A. Connolly · Clinical Trials and Surveys Corporation

Ram Kalpatthi · Children's Mercy Hospital

Russell E. Ware · Boston Children's Hospital

Winfred C. Wang · St. Jude Children's Research Hospital

Lori Luchtman‐Jones · Children's National

Myron A. Waclawiw

Abstract

Hydroxyurea does not appear to have significant deleterious effects on the immune function of infants and children with SCD. Additional assessments of lymphocyte parameters of hydroxyurea-treated children may be warranted. No changes in current immunization schedules are recommended; however, for endemic disease or epidemics, adherence to accelerated immunization schedules for the measles, mumps, and rubella vaccine should be reinforced.

Topics & Keywords

Hemoglobinopathies and Related Disorders Blood groups and transfusion Iron Metabolism and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PEDIATRICS

Volume 134, Issue 4, pp. 686-695

DOI: 10.1542/peds.2014-0571

Field-Weighted Citation Impact: 3.15