Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis

2010163 citationsJournal Article

Authors

Antje Prasse · University Medical Center Freiburg

Gernot Zissel

Niklas Lützen

Jonas C. Schupp

Rene Schmiedlin

Elena González‐Rey · Instituto de Parasitología y Biomedicina "López - Neyra"

Anne Rensing‐Ehl · ENT and Allergy

Gerald Bacher · Debiotech (Switzerland)

Vera Lúcia de Liz Oliveira Cavalli

Abstract

This study is the first to show the immunoregulatory effect of VIP in humans, and supports the notion of inhaled VIP as an attractive future therapy to dampen exaggerated immune responses in lung disorders. Thus, the inhalation of neuropeptides may be developed into a new therapeutic principle for chronic inflammatory lung disorders in humans.

Topics & Keywords

Asthma and respiratory diseases Inhalation and Respiratory Drug Delivery S100 Proteins and Annexins

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 182, Issue 4, pp. 540-548

DOI: 10.1164/rccm.200909-1451oc

Field-Weighted Citation Impact: 6.15