Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

2008587 citationsJournal Articlehybrid Open Access

Authors

Colm Cunningham · Trinity College

Suzanne Campion · University of Southampton

Katie Lunnon · University of Southampton

Carol Murray

Jack Woods

Robert M. J. Deacon · University of Oxford

J. N. P. Rawlins · University of Oxford

V. Hugh Perry ·

Abstract

These data demonstrate that transient systemic inflammation superimposed on neurodegenerative disease acutely exacerbates cognitive and motor symptoms of disease and accelerates disease progression. These deleterious effects of systemic inflammation have implications for the treatment of chronic neurodegeneration and associated delirium.

Topics & Keywords

Tryptophan and brain disorders Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Biological Psychiatry

Volume 65, Issue 4, pp. 304-312

DOI: 10.1016/j.biopsych.2008.07.024

Field-Weighted Citation Impact: 7.91