Natural Killer (NK) Cell Receptors' Repertoire in Couples with Recurrent Spontaneous Abortions

200393 citationsJournal Article

Authors

M. Varla-Leftherioti · General Hospital of Athens G. Genimatas

Maria Spyropoulou‐Vlachou · General Hospital of Athens G. Genimatas

Demetra Niokou · General Hospital of Athens G. Genimatas

Theodora Keramitsoglou · Hôpital Saint-Louis

Areti Darlamitsou · General-Maternity District Hospital Helena Venizelou

Christina Tsekoura · General-Maternity District Hospital Helena Venizelou

Abstract

Women with alloimmune abortions have a limited inhibiting KIR repertoire and such miscarriages may occur because trophoblastic HLA class I molecules are recognized by decidual NK cells lacking the appropriate inhibitory KIRs.

Topics & Keywords

Immune Cell Function and Interaction Reproductive System and Pregnancy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Reproductive Immunology

Volume 49, Issue 3, pp. 183-191

DOI: 10.1034/j.1600-0897.2003.00018.x

Field-Weighted Citation Impact: 1.90