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MicroRNA-145 Targeted Therapy Reduces Atherosclerosis

2012275 citationsJournal Articlebronze Open Access

Authors

Fina Lovren · McMaster University

Yi Pan · McMaster University

Adrian Quan · University of Toronto

Krishna K. Singh · McMaster University

Praphulla Chandra Shukla · McMaster University

Nandini Gupta · University of Toronto

Brent M. Steer ·

Abstract

VSMC-specific overexpression of microRNA-145 is a novel in vivo therapeutic target to limit atherosclerotic plaque morphology and cellular composition, shifting the balance toward plaque stability vs plaque rupture.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Kruppel-like factors research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 126, Issue 11_suppl_1, pp. S81-90

DOI: 10.1161/circulationaha.111.084186

Field-Weighted Citation Impact: 8.04

MicroRNA-145 Targeted Therapy Reduces Atherosclerosis | Researchclopedia

McMaster University

Alistair J. Ingram · McMaster University

Milan Gupta · University of Toronto

Mohammed Al‐Omran · University of Toronto

Hwee Teoh · King Saud University

Philip A. Marsden · McMaster University

Subodh Verma · King Saud University