Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers

2000152 citationsJournal Article

Authors

Gail M. Annich · University of Michigan–Ann Arbor

Jürgen Meinhardt · University Medical Centre Mannheim

Kelly A. Mowery · Merz (Germany)

Brian A. Ashton · University Medical Centre Mannheim

Scott I. Merz · University Medical Centre Mannheim

Ronald B. Hirschl · Wockhardt (United States)

Mark E. Meyerhoff

Abstract

The incorporation of NO into the surface of extracorporeal circuits reduces platelet consumption and eliminates the need for systemic heparinization in a rabbit model of extracorporeal circulation.

Topics & Keywords

Mechanical Circulatory Support Devices Nitric Oxide and Endothelin Effects Cardiac Arrest and Resuscitation

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Critical Care Medicine

Volume 28, Issue 4, pp. 915-920

DOI: 10.1097/00003246-200004000-00001

Field-Weighted Citation Impact: 9.23