Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

2012606 citationsJournal Articlegold Open Access

Authors

Chien‐Te K. Tseng · The University of Texas Medical Branch at Galveston

Elena Sbrana · The University of Texas Medical Branch at Galveston

Naoko Iwata‐Yoshikawa · The University of Texas Medical Branch at Galveston

Patrick C. Newman · The University of Texas Medical Branch at Galveston

Tania Garron · The University of Texas Medical Branch at Galveston

Robert L. Atmar · Baylor College of Medicine

Abstract

These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research Respiratory viral infections research Animal Virus Infections Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 4, pp. e35421-e35421

DOI: 10.1371/journal.pone.0035421

Field-Weighted Citation Impact: 4.07