Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

2011971 citationsJournal Articlebronze Open Access

Authors

Slaheddine Marrakchi · Inserm

Philippe Guigue · Inserm

Blair R. Renshaw · Amgen (Germany)

Anne Puel · Hôpital Necker-Enfants Malades

Xue-Yuan Pei · University of Cambridge

Sylvie Fraïtag · Inserm

Jihen Zribi · Université Paris Cité

Abstract

Aberrant interleukin-36Ra structure and function lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis. (Funded by Agence Nationale de la Recherche and Société Française de Dermatologie.).

Topics & Keywords

Psoriasis: Treatment and Pathogenesis Asthma and respiratory diseases Dermatology and Skin Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 365, Issue 7, pp. 620-628

DOI: 10.1056/nejmoa1013068

Field-Weighted Citation Impact: 24.21