Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

20051,875 citationsJournal Articlegold Open Access

Authors

Martin J. Vincent · National Center for Infectious Diseases

Éric Bergeron · Montreal Clinical Research Institute

Suzanne Benjannet · Université de Montréal

Bobbie R. Erickson · Centers for Disease Control and Prevention

Pierre E. Rollin · Centers for Disease Control and Prevention

Thomas G. Ksiazek · Centers for Disease Control and Prevention

Nabil G. Seidah

Abstract

Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

Topics & Keywords

SARS-CoV-2 and COVID-19 Research COVID-19 Clinical Research Studies Animal Virus Infections Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Virology Journal

Volume 2, Issue 1, pp. 69-69

DOI: 10.1186/1743-422x-2-69

Field-Weighted Citation Impact: 3.91