Selective homocysteine turn-on fluorescent probes and their bioimaging applications

2014155 citationsJournal Article

Authors

Hye Yeon Lee · Ewha Womans University

Yoon Pyo Choi · Yonsei University

Sun Kyung Kim · Sungkyunkwan University

Tae‐Jin Yoon · Yonsei University

Zhiqian Guo · East China University of Science and Technology

Songyi Lee · Ewha Womans University

K.M.K. Swamy ·

Abstract

The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

Topics & Keywords

Sulfur Compounds in Biology Molecular Sensors and Ion Detection Folate and B Vitamins Research

Publication Details

Published in: Chemical Communications

Volume 50, Issue 53, pp. 6967-6967

DOI: 10.1039/c4cc00243a

Field-Weighted Citation Impact: 13.56

Command Palette

Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Authors

Abstract

Topics & Keywords

Publication Details