Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival

2009195 citationsJournal Articlegold Open Access

Authors

Hisatsugu Koshimizu · National Institute of Advanced Industrial Science and Technology

Kazuyuki Kiyosue · National Institute of Advanced Industrial Science and Technology

Tomoko Hara · Japan Science and Technology Agency

Shunsuke Hazama · Osaka University

Shingo Suzuki · National Institute of Advanced Industrial Science and Technology

Koichi Uegaki · National Institute of Advanced Industrial Science and Technology

Abstract

These results suggest that proBDNF has distinct functions in different populations of CNS neurons and might be responsible for specific physiological cellular processes in the brain.

Topics & Keywords

Nerve injury and regeneration Neurogenesis and neuroplasticity mechanisms Signaling Pathways in Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Brain

Volume 2, Issue 1, pp. 27-27

DOI: 10.1186/1756-6606-2-27

Field-Weighted Citation Impact: 3.81