Novel neutral imidazole-lipophosphoramides for transfection assays

200867 citationsJournal Article

Authors

Mathieu Mével · Centre National de la Recherche Scientifique

CECILE NEVEU · Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique

Cristine Gonçalves · Centre National de la Recherche Scientifique

Jean‐Jacques Yaouanc · Université de Bretagne Occidentale

Chantal Pichon · Université d'Orléans

Paul‐Alain Jaffrès · Université de Bretagne Occidentale

Patrick Midoux

Abstract

New helper lipids, possessing an imidazole polar head, have been synthesized and included in formulations for transfection assays; these new helper lipids can improve the transfection by a factor of up to 100 compared to the use of DOPE as co-lipid.

Topics & Keywords

RNA Interference and Gene Delivery Advanced biosensing and bioanalysis techniques DNA and Nucleic Acid Chemistry

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Chemical Communications

DOI: 10.1039/b805226c

Field-Weighted Citation Impact: 2.15