Transplacental Effects of 3'-Azido-2',3'-Dideoxythymidine (AZT): Tumorigenicity in Mice and Genotoxicity in Mice and Monkeys

1997226 citationsJournal Articlebronze Open Access

Authors

Ofelia A. Olivero · National Cancer Institute

Stuart H. Yuspa · National Cancer Institute

Miriam C. Poirier · National Cancer Institute

Lucy M. Anderson · Frederick National Laboratory for Cancer Research

Ann B. Jones · Frederick National Laboratory for Cancer Research

Chunguang Wang · National Cancer Institute

Bhalchandra A. Diwan

Abstract

AZT is genotoxic in fetal mice and monkeys and is a moderately strong transplacental carcinogen in mice examined at 1 year of age. Careful long-term follow-up of AZT-exposed children would seem to be appropriate.

Topics & Keywords

Epigenetics and DNA Methylation Renal and related cancers Acute Lymphoblastic Leukemia research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 89, Issue 21, pp. 1602-1608

DOI: 10.1093/jnci/89.21.1602

Field-Weighted Citation Impact: 6.35