Leukemia cells induce changes in human bone marrow stromal cells

201361 citationsJournal Articlegold Open Access

Authors

Sara Civini · National Institutes of Health

Ping Jin · National Institutes of Health

Jiaqiang Ren · National Institutes of Health

Marianna Sabatino · National Institutes of Health Clinical Center

Luciano Castiello · National Institutes of Health Clinical Center

Jianjian Jin · National Institutes of Health

Huan Wang

Abstract

BMSCs react to the presence of leukemia cells undergoing changes in the cytokine and chemokine secretion profiles. Thus, BMSCs and leukemia cells both contribute to the creation of a competitive niche more favorable for leukemia stem cells.

Topics & Keywords

Mesenchymal stem cell research Hematopoietic Stem Cell Transplantation Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Translational Medicine

Volume 11, Issue 1, pp. 298-298

DOI: 10.1186/1479-5876-11-298

Field-Weighted Citation Impact: 3.15