Identification of Virus-Encoded MicroRNAs

20041,605 citationsJournal Article

Authors

Sébastien Pfeffer · Institute of Medical Microbiology and Hygiene

Mihaela Zavolan · Institute of Medical Microbiology and Hygiene

Friedrich A. Grässer · Memorial Sloan Kettering Cancer Center

Minchen Chien · Universitätsklinikum des Saarlandes

James J. Russo · Institute of Medical Microbiology and Hygiene

Jingyue Ju · Institute of Medical Microbiology and Hygiene

Bino John

Abstract

RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression.

Topics & Keywords

Plant Virus Research Studies Viral-associated cancers and disorders Animal Virus Infections Studies

Publication Details

Published in: Science

Volume 304, Issue 5671, pp. 734-736

DOI: 10.1126/science.1096781

Field-Weighted Citation Impact: 115.76

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Identification of Virus-Encoded MicroRNAs

Authors

Abstract

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Publication Details