Phospholipid Association Reduces The Gastric Mucosal Toxicity of Aspirin in Human Subjects

1999105 citationsJournal Article

Authors

Bhupinderjit S. Anand · Baylor College of Medicine

Sudershan K. Sanduja · NewGen Therapeutics (United States)

Lenard M. Lichtenberger · Integra (United States)

Abstract

The present study shows that acute aspirin-induced damage to the gastric mucosa can be reduced by chemically associating ASA with PC. The mechanism of mucosal protection provided by this compound is not related to any alteration in the ability of ASA to inhibit mucosal COX activity. We believe this protection is attributable to the maintenance of the defensive hydrophobic barrier of the gastric mucosa.

Topics & Keywords

Inflammatory mediators and NSAID effects Antiplatelet Therapy and Cardiovascular Diseases Helicobacter pylori-related gastroenterology studies

Publication Details

Published in: The American Journal of Gastroenterology

Volume 94, Issue 7, pp. 1818-1822

DOI: 10.1111/j.1572-0241.1999.01211.x

Field-Weighted Citation Impact: 2.88

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Phospholipid Association Reduces The Gastric Mucosal Toxicity of Aspirin in Human Subjects

Authors

Abstract

Topics & Keywords

Publication Details