Cell Therapy of Stage IV Nasopharyngeal Carcinoma With Autologous Epstein-Barr Virus–Targeted Cytotoxic T Lymphocytes

2005280 citationsJournal Articlebronze Open Access

Authors

Patrizia Comoli · Istituti di Ricovero e Cura a Carattere Scientifico

Paolo Pedrazzoli · Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Rita Maccario · Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Sabrina Basso · Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Ornella Carminati · Istituti di Ricovero e Cura a Carattere Scientifico

Massimo Labirio · Istituti di Ricovero e Cura a Carattere Scientifico

Abstract

Cell therapy with EBV-targeted autologous CTLs is safe, induces LMP-2-specific immunologic responses, and is associated with objective responses and control of disease progression in patients with stage IV NPC resistant to conventional treatments.

Topics & Keywords

Viral-associated cancers and disorders Parvovirus B19 Infection Studies Histiocytic Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 23, Issue 35, pp. 8942-8949

DOI: 10.1200/jco.2005.02.6195

Field-Weighted Citation Impact: 5.33